Title : Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells.

Pub. Date : 1998 Jan 22

PMID : 9467962






6 Functional Relationships(s)
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1 The maximum induced p21 levels in the absence of Tet were estimated to be ten times that of endogenous hamster p21. Tetracycline cyclin dependent kinase inhibitor 1A Homo sapiens
2 As p21 levels rose following removal of Tet, p21-associated histone H1 kinase activity was increased and concomitantly cell growth and DNA synthesis were reduced. Tetracycline cyclin dependent kinase inhibitor 1A Homo sapiens
3 As p21 levels rose following removal of Tet, p21-associated histone H1 kinase activity was increased and concomitantly cell growth and DNA synthesis were reduced. Tetracycline cyclin dependent kinase inhibitor 1A Homo sapiens
4 Tet-p21 BHK21 cells became arrested in G1 phase and lost colony forming ability irreversibly 2-4 days after removal of Tet. Tetracycline cyclin dependent kinase inhibitor 1A Homo sapiens
5 Tet-p21 BHK21 cells became arrested in G1 phase and lost colony forming ability irreversibly 2-4 days after removal of Tet. Tetracycline cyclin dependent kinase inhibitor 1A Homo sapiens
6 The induction of cyclin E- and cyclin A-associated kinase activities was diminished when G0-synchronized Tet-p21 BHK21 cells were serum stimulated in the absence of Tet. Tetracycline cyclin dependent kinase inhibitor 1A Homo sapiens