Title : Generation of reactive oxygen species in a human keratinocyte cell line: role of calcium.

Pub. Date : 1998 Feb 1

PMID : 9466814






3 Functional Relationships(s)
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1 In the human keratinocyte cell line HaCaT, reactive oxygen species (ROS) were generated in a dose- and time-dependent manner in response to epidermal growth factor (EGF), bradykinin, thapsigargin, and the Ca(2+)-ionophore A23187, agonists that interact with different primary cell targets. Reactive Oxygen Species kininogen 1 Homo sapiens
2 In the human keratinocyte cell line HaCaT, reactive oxygen species (ROS) were generated in a dose- and time-dependent manner in response to epidermal growth factor (EGF), bradykinin, thapsigargin, and the Ca(2+)-ionophore A23187, agonists that interact with different primary cell targets. Reactive Oxygen Species kininogen 1 Homo sapiens
3 The ROS evoked by EGF and bradykinin decayed within 8 and 4 min, respectively, this transient effect resulting probably from down-regulation of the specific agonist receptors or dissipation of the secondary signals. Reactive Oxygen Species kininogen 1 Homo sapiens