Title : Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma.

Pub. Date : 1998 Feb

PMID : 9463483






1 Functional Relationships(s)
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1 FUra-mediated thymidylate synthase inhibition was accompanied by a 124-fold increase in total deoxyuridylate immunoreactivity and a 31-fold increase in dUTP pools, but the addition of IFN-alpha + gamma attenuated the accumulation. 2'-deoxyuridylic acid thymidylate synthetase Homo sapiens