Title : Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors.

Pub. Date : 1998 Jan 2

PMID : 9462845






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 With an unequivocal (2S,3S) configuration this new trans-epoxysuccinyl peptide derivative was found to inhibit cathepsin B with an apparent second-order rate constant of 1,520,000 M(-1) s(-1) which represents so far the most potent inhibitor among E-64-derived compounds. Saccharin cathepsin B Homo sapiens