Title : Multiple residues contribute independently to differences in ligand recognition between vesicular monoamine transporters 1 and 2.

Pub. Date : 1998 Feb 13

PMID : 9461580






2 Functional Relationships(s)
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1 In contrast, the replacement of many residues in TMD5-8 of VMAT2 with equivalent residues from VMAT1 improves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12. Serotonin solute carrier family 18 member A2 Homo sapiens
2 In contrast, the replacement of many residues in TMD5-8 of VMAT2 with equivalent residues from VMAT1 improves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12. Serotonin solute carrier family 18 member A2 Homo sapiens