Pub. Date : 1998 Feb
PMID : 9458362
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells. | Tretinoin | cyclin D1 | Homo sapiens |
| 2 | We examined the effects of all-trans retinoic acid (RA) on the insulin-induced cell growth, cell cycle progression and cyclin D1 gene expression in breast cancer cells. | Tretinoin | cyclin D1 | Homo sapiens |
| 3 | The RA antagonism of insulin growth effect was associated with an inhibition of cell cycle progression and a suppression of insulin-induced cyclin D1 mRNA. | Tretinoin | cyclin D1 | Homo sapiens |
| 4 | The effect of RA on cyclin D1 mRNA was dose-dependent and was observed within 5 h of treatment when insulin response was maximal. | Tretinoin | cyclin D1 | Homo sapiens |