Title : Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

Pub. Date : 1998 Feb 1

PMID : 9458081






1 Functional Relationships(s)
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1 Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs reduce the risk of colon cancer and that the inhibition of colon carcinogenesis is mediated through modulation of prostaglandin production by cyclooxygenase (COX) isozymes (COX-1 and -2). Prostaglandins cytochrome c oxidase I, mitochondrial Rattus norvegicus