Title : Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture.

Pub. Date : 1998 Feb

PMID : 9454825






1 Functional Relationships(s)
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1 The observed changes in the activity and protein levels of CYP1A2 and CYP3A4 correlated with a reduction in the specific messenger RNA levels both in control, 3-methylcholanthrene-treated (for CYP1A2) and rifampicin-treated (for CYP3A4) hepatocytes, which thus suggested that HGF could down-regulate CYP expression at a pretranslational level. Rifampin cytochrome P450 family 1 subfamily A member 2 Homo sapiens