Title : Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells.

Pub. Date : 1997 Dec

PMID : 9453463






2 Functional Relationships(s)
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1 Migration induced by either LPA or thrombin was inhibited by the actin cytoskeleton-disrupting agent, cytochalasin B, by the Rho protein-inactivating Clostridium difficile toxin B, by preventing [Ca2+]i transients with an intracellular calcium-chelating agent, and by the phorbol ester, phorbol 12-myristate 13-acetate, which also blocked the LPA- and thrombin-induced [Ca2+]i increases. lysophosphatidic acid coagulation factor II, thrombin Homo sapiens
2 Migration induced by either LPA or thrombin was inhibited by the actin cytoskeleton-disrupting agent, cytochalasin B, by the Rho protein-inactivating Clostridium difficile toxin B, by preventing [Ca2+]i transients with an intracellular calcium-chelating agent, and by the phorbol ester, phorbol 12-myristate 13-acetate, which also blocked the LPA- and thrombin-induced [Ca2+]i increases. lysophosphatidic acid coagulation factor II, thrombin Homo sapiens