Title : The first extracellular domain of corticotropin releasing factor-R1 contains major binding determinants for urocortin and astressin.

Pub. Date : 1998 Feb

PMID : 9449626






1 Functional Relationships(s)
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1 The complementary chimera in which E1 domain of the GRF-R was replaced by that of the CRF-R1 bound astressin and urocortin with Ki values approximately 10 nM, compared with inhibitory binding dissociation constant (Ki) values of approximately 2-4 nM for the wild-type CRF-R1. Urocortins corticotropin releasing hormone receptor 1 Rattus norvegicus