Pub. Date : 1997 Dec
PMID : 9447822
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In order to determine the role of p-glycoprotein in the cellular pharmacology of mitoxantrone flow cytometry and confocal microscopy were used to study two human myeloid leukemia cell lines selected for resistance to mitoxantrone (HL-60MX2) and doxorubicin (HL-60DOX). | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In contrast, 3.1- and 2.4-fold increases were found in uptake and retention of mitoxantrone in p-glycoprotein-positive cells (HL-60DOX) incubated with verapamil. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Our study demonstrates that the cellular pharmacology of mitoxantrone is affected by p-glycoprotein and can be reversed at least in part by verapamil. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |