Title : An induced proximity model for caspase-8 activation.

Pub. Date : 1998 Jan 30

PMID : 9446604






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The assembly of the CD-95 (Fas/Apo-1) receptor death-inducing signaling complex occurs in a hierarchical manner; the death domain of CD-95 binds to the corresponding domain in the adapter molecule Fas-associated death domain (FADD) Mort-1, which in turn recruits the zymogen form of the death protease caspase-8 (FLICE/Mach-1) by a homophilic interaction involving the death effector domains. ammonium ferrous sulfate caspase 8 Homo sapiens
2 The assembly of the CD-95 (Fas/Apo-1) receptor death-inducing signaling complex occurs in a hierarchical manner; the death domain of CD-95 binds to the corresponding domain in the adapter molecule Fas-associated death domain (FADD) Mort-1, which in turn recruits the zymogen form of the death protease caspase-8 (FLICE/Mach-1) by a homophilic interaction involving the death effector domains. ammonium ferrous sulfate caspase 8 Homo sapiens