Pub. Date : 1998 Jan
PMID : 9443942
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells. | Anthracyclines | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 2 | The substrate specificity of both transporter proteins is partly overlapping but is otherwise very distinct; because MRP is a multiple organic anion transporter, it transports certain glutathione conjugates and may be partly dependent on intracellular glutathione levels for the transport of anthracyclines. | Anthracyclines | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 3 | We have studied the transport kinetics of a series of anthracyclines in MRP and Pgp that overexpress tumor cell lines to obtain information on the substrate specificity of these proteins. | Anthracyclines | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 4 | Two anthracyclines, the doxorubicin derivative pirarubicin and 2"-bromo-4"-epi-DNR seemed to have a slightly higher Ka value for Pgp than for MRP. | Anthracyclines | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 5 | Determination of the Hill coefficient (nH) of the MRP-mediated efflux gave most values close to 2, which suggests cooperativity of the transport of anthracyclines as reported before for Pgp. | Anthracyclines | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 6 | In conclusion, the transport kinetics of anthracyclines by MRP and Pgp are very similar. | Anthracyclines | ATP binding cassette subfamily C member 1 | Homo sapiens |