Pub. Date : 1998 Jan
PMID : 9440732
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 protein accumulation predicts poor response to tamoxifen therapy of patients with recurrent breast cancer. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 2 | We studied whether p53 protein accumulation is a predictive factor for response to tamoxifen treatment in patients with recurrent breast cancer. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 3 | In a test for trend, we observed an association of p53 protein levels with response to tamoxifen therapy. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 4 | Also in multivariate analysis, reduced survival after the start of tamoxifen therapy was observed in the p53-high group (relative hazards rate [RHR], 1.56, 95% CI, 1.17 to 2.10; P = .002). | Tamoxifen | tumor protein p53 | Homo sapiens |
| 5 | A statistically significant association between p53 levels and decreased tamoxifen response was seen only in the subset of patients whose tumors expressed low levels of ER or PgR (<75 fmol/mg protein). | Tamoxifen | tumor protein p53 | Homo sapiens |
| 6 | CONCLUSION: Measurement of primary tumor p53 levels may be effective in predicting response to tamoxifen therapy in recurrent breast disease. | Tamoxifen | tumor protein p53 | Homo sapiens |