Title : Effects of repeated MK-801 administration on the glutamate receptor gene expression in the rat hippocampus.

Pub. Date : 1997 Aug

PMID : 9437768






3 Functional Relationships(s)
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1 An in situ hybridization study showed that a single injection of MK-801 increased the NMDAR1 mRNA level in the CA1 region after 3 and 24 h, and in the CA3 one after 3 h, whereas chronic administration of the drug increased the mRNA level in the dentate gyrus and CA1 at the latter time. Dizocilpine Maleate carbonic anhydrase 1 Rattus norvegicus
2 An in situ hybridization study showed that a single injection of MK-801 increased the NMDAR1 mRNA level in the CA1 region after 3 and 24 h, and in the CA3 one after 3 h, whereas chronic administration of the drug increased the mRNA level in the dentate gyrus and CA1 at the latter time. Dizocilpine Maleate carbonic anhydrase 1 Rattus norvegicus
3 Chronic MK-801 administration decreased GluR2 flip mRNA level in the dentate gyrus at 3 and 24 h, and in the CA1 region at 3 h only. Dizocilpine Maleate carbonic anhydrase 1 Rattus norvegicus