Pub. Date : 1997 Dec
PMID : 9430371
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study addressed the question whether the inhibitory effect of lovastatin on premitotic DNA synthesis correlates with a downregulation of c-fos mRNA levels, a marker of signaling efficiency, in human SMC. | Lovastatin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Lovastatin efficiently inhibited [3H]thymidine uptake promoted by all mitogens tested (76-87%); however, it significantly inhibited upregulation of c-fos mRNA levels induced only by insulin (33-67%, P < 0.05) and IGF-I (31 57%, P < 0.05). | Lovastatin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |