Pub. Date : 1997 Dec 1
PMID : 9428742
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The ABC transporter Atm1p is required for mitochondrial iron homeostasis. | Iron | ATP binding cassette subfamily B member 7 | Homo sapiens |
| 2 | Mitochondria deficient in Atm1p accumulate 30-fold higher levels of free iron as compared to wild-type organelles, i.e. three-fold more than mitochondria deficient in frataxin, the protein mutated in Friedreich"s ataxia. | Iron | ATP binding cassette subfamily B member 7 | Homo sapiens |
| 3 | The increased mitochondrial iron content may be causative of the oxidative damage of heme-containing proteins in delta atm1 cells. | Iron | ATP binding cassette subfamily B member 7 | Homo sapiens |
| 4 | Our data assign an important function to Atm1p in mitochondrial iron homeostasis. | Iron | ATP binding cassette subfamily B member 7 | Homo sapiens |