Title : Identification of Stat 5B as a substrate of the insulin receptor.

Pub. Date : 1997 Dec 1

PMID : 9428692






1 Functional Relationships(s)
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1 We show that interaction between Stat 5B and the receptor requires a functional insulin-receptor kinase, Tyr960 of insulin receptor is implicated in the interaction with Stat 5B, whereas asparagine and proline forming the NPEY960-motif are not, and Stat 5B mutated at Thr684, a potential phosphorylation site of mitogen-activated protein kinase, loses its ability to interact with the insulin receptor. Proline insulin Homo sapiens