Title : The role of cysteine residues in S100B dimerization and regulation of target protein activity.

Pub. Date : 1997 Nov 14

PMID : 9428666






4 Functional Relationships(s)
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1 The role of cysteine residues in S100B dimerization and regulation of target protein activity. Cysteine S100 calcium binding protein B Homo sapiens
2 Previous studies have demonstrated that the two cysteine residues in the calcium-binding protein S100B are required for its extracellular functions. Cysteine S100 calcium binding protein B Homo sapiens
3 In addition, S100B proteins containing two, one or no cysteine residues behaved as dimers in size exclusion chromatography experiments in the presence or absence of calcium as well as in the presence or absence of reducing agent. Cysteine S100 calcium binding protein B Homo sapiens
4 In summary, cysteine residues are not necessary for the noncovalent dimerization of S100B, but are important in certain S100B target protein-interactions. Cysteine S100 calcium binding protein B Homo sapiens