Title : Allosteric control of acetylcholinesterase activity by monoclonal antibodies.

Pub. Date : 1998 Jan 6

PMID : 9425034






2 Functional Relationships(s)
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1 The mechanism of inhibition of acetylcholinesterase by these monoclonal antibodies was further investigated by determining their effect on (i) substrate inhibition due to the binding of excess substrate to the peripheral anionic site and (ii) binding of peripheral anionic site ligands, such as propidium and fasciculin. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The results also show that propidium clearly slowed the inhibition of fetal bovine serum acetylcholinesterase by all six inhibitory monoclonal antibodies but to different levels. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens