Title : High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

Pub. Date : 1998 Jan 1

PMID : 9421478






2 Functional Relationships(s)
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1 We tested if structural analogues of D-glucose may mimic the high glucose effect and found that D-glucosamine was strikingly more potent than D-glucose itself in enhancing the production of TGF-beta protein and subsequent production of the matrix components heparan sulfate proteoglycan and fibronectin in a time- and dose-dependent manner. Glucosamine transforming growth factor beta 1 Homo sapiens
2 D-Glucosamine also promoted conversion of latent TGF-beta to the active form. Glucosamine transforming growth factor beta 1 Homo sapiens