Title : Cyclic GMP-dependent protein kinase activation in the absence of negative inotropic effects in the rat ventricle.

Pub. Date : 1997 Dec

PMID : 9421291






1 Functional Relationships(s)
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1 It has been suggested that activation of cyclic GMP-dependent protein kinase (PKG) is a necessary step in the chain of events leading to the production of negative inotropy by muscarinic receptor agonists in mammalian ventricles, and that some cyclic GMP-elevating agents, such as sodium nitroprusside (SNP), fail to exert a negative inotropic effect because they elevate cyclic GMP levels in a pool that does not activate the kinase. Nitroprusside protein kinase cGMP-dependent 1 Homo sapiens