Title : Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation.

Pub. Date : 1997 Nov 25

PMID : 9417881






1 Functional Relationships(s)
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1 To understand the role of protein kinases in the heat-induced p53-mediated signal transduction pathway, the effects of H-7, a serine/threonine kinase inhibitor, on WAF1 accumulation were investigated using two human glioblastoma cell lines differing in p53 status or their transfectants with various p53-expression vectors. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine cyclin dependent kinase inhibitor 1A Homo sapiens