Pub. Date : 1998 Jan 2
PMID : 9417076
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proteolipid protein (PLP), the major protein of central nervous system myelin, contains covalently bound fatty acids, predominantly palmitic acid. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |
| 2 | Proteolipid protein (PLP), the major protein of central nervous system myelin, contains covalently bound fatty acids, predominantly palmitic acid. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |
| 3 | Palmitic acid derived from PLP acquired increasing amounts of 18O, ending with 2.9% 18O enrichment after 6 h of incubation. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |
| 4 | After correcting for the specific activity of the 18O-enriched free palmitic acid pool, 7.6% of the PLP molecules were found to acquire palmitic acid in 6 h. This value is not only too large to be the result of the palmitoylation of newly synthesized PLP molecules, it was also unchanged upon the inhibition of protein synthesis with cycloheximide. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |
| 5 | After correcting for the specific activity of the 18O-enriched free palmitic acid pool, 7.6% of the PLP molecules were found to acquire palmitic acid in 6 h. This value is not only too large to be the result of the palmitoylation of newly synthesized PLP molecules, it was also unchanged upon the inhibition of protein synthesis with cycloheximide. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |
| 6 | After correcting for the specific activity of the 18O-enriched free palmitic acid pool, 7.6% of the PLP molecules were found to acquire palmitic acid in 6 h. This value is not only too large to be the result of the palmitoylation of newly synthesized PLP molecules, it was also unchanged upon the inhibition of protein synthesis with cycloheximide. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |
| 7 | In conclusion, our experiments suggest that a substantial proportion of PLP molecules acquire palmitic acid via an acylation/deacylation cycle and that this profile changes during development. | Palmitic Acid | proteolipid protein 1 | Rattus norvegicus |