Title : Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis.

Pub. Date : 1997 Nov

PMID : 9409301






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inactivation of the apoE gene in mice leads to a prominent increase in serum cholesterol and triglyceride levels and the development of premature atherosclerosis. Cholesterol apolipoprotein E Mus musculus
2 These low concentrations of apoE nevertheless dramatically reduced serum cholesterol levels owing to a reduction of VLDL and, to a lesser extent, LDL, while HDL levels were slightly raised. Cholesterol apolipoprotein E Mus musculus