Pub. Date : 1997 Jul
PMID : 9408089
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone (DEX) is extensively metabolized to 6-hydroxyDEX (6OH-DEX) and side-chain cleaved metabolites in human liver both in vitro and in vivo with CYP3A4 responsible for the formation of 6-hydroxylated products. | Dexamethasone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Dexamethasone (DEX) is extensively metabolized to 6-hydroxyDEX (6OH-DEX) and side-chain cleaved metabolites in human liver both in vitro and in vivo with CYP3A4 responsible for the formation of 6-hydroxylated products. | Dexamethasone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | However, 6-hydroxylation was most extensive in the hamster which may therefore be a suitable model to use for further studies on DEX metabolism by CYP3A. | Dexamethasone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |