Pub. Date : 1997 Jul
PMID : 9408086
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of danazol and progesterone on sex hormone-binding globulin mRNA expression in human endometrial cancer cell line Ishikawa. | Danazol | sex hormone binding globulin | Homo sapiens |
| 2 | Danazol and progesterone significantly (P < 0.05) suppressed the expression of SHBG mRNA dose-dependently starting at a concentration of 10(-6) and 10(-8) M, respectively. | Danazol | sex hormone binding globulin | Homo sapiens |
| 3 | The time course study showed the time-dependent decrease of SHBG mRNA level by danazol and progesterone (10[-6] M) with or without E2 (10[-8] M), except for a temporal increase by progesterone. | Danazol | sex hormone binding globulin | Homo sapiens |
| 4 | These findings suggest that danazol and progesterone in a superphysiological milieu down-regulate the intracellular SHBG-related steroidal actions, and that progesterone in a physiological milieu with estrogen up-regulates it in a hormone-dependent cell line. | Danazol | sex hormone binding globulin | Homo sapiens |
| 5 | A decrease of intracellular SHBG caused by high-dose danazol or progesterone might partly contribute to the abolition of the intracellular estrogen-dominant milieu, and be related to the inhibition of estrogen-dependent growth of some endometrial cancer cells. | Danazol | sex hormone binding globulin | Homo sapiens |