Title : Pig hepatocytes as an in vitro model to study the regulation of human CYP3A4: prediction of drug-drug interactions with 17 alpha-ethynylestradiol.

Pub. Date : 1997 Nov 6

PMID : 9402952






1 Functional Relationships(s)
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1 The drugs known to be inducers of CYP3A4 in humans significantly increased a CYP isoform in pigs catalyzing 6 beta-hydroxylation of testosterone and 2-hydroxylation of EE2, whereas drugs not reported to have clinical interactions with EE2 had no or only marginal effect. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens