Title : Interaction of the human protein kinase PKR with the mouse PKR homolog occurs via the N-terminal region of PKR and does not inactivate autophosphorylation activity of mouse PKR.

Pub. Date : 1997 Nov 24

PMID : 9400613






2 Functional Relationships(s)
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1 Intraspecies PKR interactions were more efficient than interspecies PKR interactions, and interactions between RNA-binding-sufficient PKR proteins were more efficient than those involving an RNA-binding mutant as measured by binding to GST-PKR protein Sepharose beads. Sepharose glutathione S-transferase kappa 1 Homo sapiens
2 Purified mouse full-length PKR(1-515)WT GST fusion protein retained kinase activity on Sepharose beads, but the activity was not impaired by association with either the full-length or the N-terminal region of human PKR. Sepharose glutathione S-transferase kappa 1 Homo sapiens