Title : Recombinant murine tumor necrosis factor-alpha inhibits cholesterol side-chain cleavage cytochrome P450 and insulin-like growth factor-I gene expression in rat Leydig cells.

Pub. Date : 1994 May

PMID : 9397943






4 Functional Relationships(s)
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1 In primary cultures of Leydig cells, we found that in the presence of hCG (10 ng/ml), testosterone levels were markedly elevated, 69.3 +/- 3.1 ng/10(6) cells/h (mean + SE). Testosterone glycoprotein hormones, alpha polypeptide Homo sapiens
2 TNF-alpha (10 ng/ml) inhibited hCG (0.1, 1 and 10 ng/ml)-induced testosterone formation by 63%, 67% and 61%, respectively. Testosterone glycoprotein hormones, alpha polypeptide Homo sapiens
3 In the present study, we demonstrated that both murine TNF-alpha and human IL-1beta were potent inhibitors of hCG-induced testosterone formation. Testosterone glycoprotein hormones, alpha polypeptide Homo sapiens
4 IL-1beta alone in concentrations of 0.1, 1 and 10 ng/ml inhibited testosterone formation by 45%, 62% and 91%, respectively, in the presence of TNF-alpha (10 ng/ml), IL-1beta in a concentration as low as 0.1 ng/ml completely blocked hCG-induced testosterone formation. Testosterone glycoprotein hormones, alpha polypeptide Homo sapiens