Pub. Date : 1997 Nov
PMID : 9396033
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of kainate-induced Ca2+ influx by ibudilast was decreased by H-89, a protein kinase A (PKA) inhibitor, but increased by okadaic acid, an inhibitor of phosphatase 1 and 2A. | ibudilast | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 2 | Inhibition of kainate-induced Ca2+ influx by ibudilast was decreased by H-89, a protein kinase A (PKA) inhibitor, but increased by okadaic acid, an inhibitor of phosphatase 1 and 2A. | ibudilast | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 3 | Therefore, we concluded that ibudilast prevented oligodendroglial excitotoxicity by a PKA-dependent phosphorylation process resulting in decreased kainate-induced Ca2+ influx. | ibudilast | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |