Title : Signal transduction pathways of membrane expression of proteinase 3 (PR-3) in human endothelial cells.

Pub. Date : 1997 Nov

PMID : 9395784






1 Functional Relationships(s)
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1 Tumour necrosis factor alpha (TNF-alpha)-induced membrane expression of PR-3 could be blocked with the RNA synthesis inhibitor actinomycin D, the protein kinase C (PKC) and proteinase A (PKA) inhibitor staurosporine, the specific PKA inhibitor calphostin C, the c-AMP-dependent PKA inhibitor KT5720 and the tyrosine kinase inhibitor genistein in a dose-dependent manner. Staurosporine tumor necrosis factor Homo sapiens