Title : Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.

Pub. Date : 1997 Dec 12

PMID : 9395516






3 Functional Relationships(s)
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Protein Name
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1 In a concentration-dependent manner, simvastatin, and to a lesser extent, lovastatin, prevented the down-regulation of ecNOS expression by hypoxia. Simvastatin nitric oxide synthase 3 Homo sapiens
2 Simvastatin-induced changes in ecNOS expression correlated with changes in endothelial NO production and were reversed by treatment with L-mevalonate. Simvastatin nitric oxide synthase 3 Homo sapiens
3 Actinomycin D studies revealed that under hypoxic conditions, simvastatin increased ecNOS mRNA half-life from 13 to 38 h. Nuclear run-on studies showed that simvastatin had no effect on repression of ecNOS gene transcription by hypoxia. Simvastatin nitric oxide synthase 3 Homo sapiens