Title : Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation.

Pub. Date : 1997 Nov

PMID : 9392422






1 Functional Relationships(s)
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1 Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells. Tetradecanoylphorbol Acetate Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens