Title : Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts.

Pub. Date : 1997 Dec

PMID : 9389508






2 Functional Relationships(s)
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1 IL-6 and IL-6sR increased immunoreactive IGF-I levels by 2.4-fold after 24 h and 6.4-fold after 48 h. Cycloheximide prevented, and indomethacin markedly decreased, the effect of IL-6 and IL-6sR on IGF-I mRNA levels, but hydroxyurea did not. Cycloheximide insulin-like growth factor 1 Rattus norvegicus
2 IL-6 and IL-6sR increased immunoreactive IGF-I levels by 2.4-fold after 24 h and 6.4-fold after 48 h. Cycloheximide prevented, and indomethacin markedly decreased, the effect of IL-6 and IL-6sR on IGF-I mRNA levels, but hydroxyurea did not. Cycloheximide insulin-like growth factor 1 Rattus norvegicus