Title : [Endothelin-1 induces chemotaxis of pulmonary artery smooth muscle cells].

Pub. Date : 1996 Oct

PMID : 9388958






6 Functional Relationships(s)
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Protein Name
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1 This study observed that ET-1 induced chemotaxis of PASMC in a dose dependent manner. pasmc endothelin 1 Homo sapiens
2 The maxium chemotactic response of PASMC to ET-1 occured at a concentration of 10(-9) mol/L. pasmc endothelin 1 Homo sapiens
3 BQ123, a specific antagonist of ETRA, significantly inhibited the chemotaxis of PASMC induced by ET-1, which indicates that the chemotactic activity of ET-1 may be mediated by ETRA. pasmc endothelin 1 Homo sapiens
4 BQ123, a specific antagonist of ETRA, significantly inhibited the chemotaxis of PASMC induced by ET-1, which indicates that the chemotactic activity of ET-1 may be mediated by ETRA. pasmc endothelin 1 Homo sapiens
5 Hypoxia enhanced the chemotaxis of PASMC induced by ET-1. pasmc endothelin 1 Homo sapiens
6 This study suggests that ET-1 and hypoxia might stimulate the migration of PASMC and/or its precorsor. pasmc endothelin 1 Homo sapiens