Title : c-Jun/AP-1, but not NF-kappa B, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells.

Pub. Date : 1997 Nov 17

PMID : 9388508






5 Functional Relationships(s)
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1 Northern blot analysis and transient transfection assays using reporter plasmids showed that H2O2 activated both AP-1 and NF-kappa B. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Downregulation of c-Jun/AP-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the H2O2-initiated apoptosis. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Downregulation of c-Jun/AP-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the H2O2-initiated apoptosis. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 Downregulation of c-Jun/AP-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the H2O2-initiated apoptosis. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
5 Downregulation of c-Jun/AP-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the H2O2-initiated apoptosis. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens