Title : Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Pub. Date : 1997 Nov

PMID : 9385632






3 Functional Relationships(s)
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1 We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex. Glycine peptidylprolyl isomerase A Homo sapiens
2 We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex. Glycine peptidylprolyl isomerase A Homo sapiens
3 Comparison with the recently determined structures of CypA in complexes with larger fragments of the HIV-1 capsid protein demonstrates that CypA recognition of these hexapeptides involves contacts with peptide residues Ala(Val) 88, Gly 89, and Pro 90, and is independent of the context of longer sequences. Glycine peptidylprolyl isomerase A Homo sapiens