Pub. Date : 1997 Nov
PMID : 9384491
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5. | desloratadine | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |
| 2 | DCL (1-100 microM) inhibited hKv1.5 current in a concentration-dependent manner with an apparent affinity constant of 12.5+/-1.2 microM. | desloratadine | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |
| 3 | The present results demonstrated that DCL blocked hKv1.5 channels in a concentration-, voltage-, and time-dependent manner. | desloratadine | potassium voltage-gated channel subfamily A member 5 | Homo sapiens |