Title : Antioxidants for prevention of methionine oxidation in recombinant monoclonal antibody HER2.

Pub. Date : 1997 Nov

PMID : 9383735






2 Functional Relationships(s)
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1 These studies demonstrate that stoichiometric amounts of methionine and thiosulfate are sufficient to eliminate temperature-induced oxidation of rhuMAb HER2 caused by free radicals that were generated by the presence of metal ion and peroxide impurities in the formulation. Thiosulfates erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 A thiosulfate adduct of rhuMAb HER2 was observed by cation-exchange chromatography. Thiosulfates erb-b2 receptor tyrosine kinase 2 Homo sapiens