Pub. Date : 1995 Jan
PMID : 9383399
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. | Hydrogen Peroxide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | RESULTS: Cell lines stably overexpressing the H2O2-degrading enzyme catalase were deficient in activating NF-kappa B in response to tumor necrosis factor alpha (TNF) or okadaic acid. | Hydrogen Peroxide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In contrast, stable overexpression of cytoplasmic Cu/Zn-dependent superoxide dismutase (SOD), which enhances the production of H2O2 from superoxide, potentiated NF-kappa B activation. | Hydrogen Peroxide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | CONCLUSIONS: Our data show that one ROI species, H2O2 acts as a messenger in the TNF- and okadaic acid-induced post-translational activation of NF-kappa B. | Hydrogen Peroxide | nuclear factor kappa B subunit 1 | Homo sapiens |