Title : The effects of antipsychotic drugs on the mRNA levels of serotonin 5HT2A and 5HT2C receptors.

Pub. Date : 1997 Aug

PMID : 9379848






1 Functional Relationships(s)
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1 Regionally, 32 days treatment with haloperidol (3 mg/kg/day), sulpiride (100 mg/kg/day) or clozapine (10 mg/kg/day) resulted in a drop of approximately 30-40% in 5HT2C mRNA levels in both cortex and cerebellum, and decreases (or non-significant trends) of 15-40% in 5HT2A mRNA levels in hippocampus, brainstem and mid brain. Haloperidol 5-hydroxytryptamine receptor 2A Rattus norvegicus