Title : Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioid receptor. A model for receptor activation.

Pub. Date : 1997 Sep 26

PMID : 9379445






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Molecular simulations of the receptor--ligand complex yielded structures in which the tyramine moiety or opioid "message" of dynorphin is bound within a conserved aromatic pocket in the transmembrane domain while the helical portion contacted residues in EL2 and in the extracellular end of transmembrane helices 6 and 7. Tyramine spectrin alpha, erythrocytic 1 Homo sapiens