Pub. Date : 1997 Oct 15
PMID : 9377582
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The c-jun-transfected MCF7 cells had increased basal AP-1 transactivation activity and increased expression of AP-1-regulated genes but were resistant to the antiproliferative effects of atRA. | Tretinoin | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | However, MCF7 cells transfected with a deletion mutant of c-jun, TAM-67, which lacks most of the amino-terminal transactivation domain of cJun and is unable to activate AP-1-dependent gene expression, were sensitive to the growth-inhibitory effects of atRA. | Tretinoin | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | However, retinoic acid responsive element DNA binding activity was intact in c-jun-transfected cells. | Tretinoin | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |