Title : Neuroprotective role of c-fos antisense oligonucleotide: in vitro and in vivo studies.

Pub. Date : 1997 Sep 8

PMID : 9376532






2 Functional Relationships(s)
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1 We investigated the dose-response and time-course of c-fos antisense oligodeoxynucleotide (ASO) treatment against excitatory amino acid (EAA)-induced neurotoxicity in rat hippocampal neurons. 1,5-anhydroglucitol Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 In vivo, bilateral intrahippocampal injections of c-fos ASO (0.025 nmol/site) was neuroprotective when administered 30 min before or after NMDA treatment. 1,5-anhydroglucitol Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus