Title : Highly sensitive and specific detection of P-glycoprotein function for haematological and solid tumour cells using a novel nucleic acid stain.

Pub. Date : 1997

PMID : 9376262






3 Functional Relationships(s)
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1 We found, in a P-gp+ leiomyosarcoma, an RF of 16 for SYTO16 and 2.7 for daunorubicin. Daunorubicin ATP binding cassette subfamily B member 1 Homo sapiens
2 This means that complete inhibition of P-gp function in these sarcoma cells would lead to an increase of daunorubicin accumulation with 170% compared with 30% in the CD34+ cells. Daunorubicin ATP binding cassette subfamily B member 1 Homo sapiens
3 Because the RF for SYTO16 is much higher than for daunorubicin, it can be applied for the determination of P-gp function in relatively small numbers of low-P-gp-expressing tumour cells by laser scanning microscopy. Daunorubicin ATP binding cassette subfamily B member 1 Homo sapiens