Title : Differential stimulation of cytosolic phospholipase A2 by bradykinin in human cystic fibrosis cell lines.

Pub. Date : 1997 Oct

PMID : 9376123






2 Functional Relationships(s)
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1 Comparison of the effects of bradykinin to those observed with thapsigargin, an inhibitor of calcium reuptake, suggests that the increase of intracellular calcium is not the only mechanism involved in arachidonic acid release by bradykinin in deltaF508 cells. Calcium kininogen 1 Homo sapiens
2 The binding of cPLA2 to membranes after bradykinin stimulation still occurred in CFT2 cells (deltaF508) homogenized in EDTA, suggesting that a membrane component plus increased intracellular calcium influenced cPLA2 anchoring to membranes. Calcium kininogen 1 Homo sapiens