Title : Niflumic acid differentially modulates two types of skeletal ryanodine-sensitive Ca(2+)-release channels.

Pub. Date : 1997 Nov

PMID : 9374644






2 Functional Relationships(s)
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1 Frog muscle had two distinct types of RyRs in the SR: one showed a bell-shaped channel activation curve against cytoplasmic Ca2+ or niflumic acid, and its mean open probability (Po) was increased by perchlorate at 20-30 mM (termed "alpha-like" RyR); the other showed a sigmoidal activation curve against Ca2+ or niflumic acid, with no effect on perchlorate (termed "beta-like" RyR). perchlorate ryanodine receptor 1 Homo sapiens
2 Frog muscle had two distinct types of RyRs in the SR: one showed a bell-shaped channel activation curve against cytoplasmic Ca2+ or niflumic acid, and its mean open probability (Po) was increased by perchlorate at 20-30 mM (termed "alpha-like" RyR); the other showed a sigmoidal activation curve against Ca2+ or niflumic acid, with no effect on perchlorate (termed "beta-like" RyR). perchlorate ryanodine receptor 1 Homo sapiens