Pub. Date : 1997 Oct 27
PMID : 9373167
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of prostaglandin G/H synthase-2 expression by arachidonic acid monoxygenase product, 14,15-epoxyeicosatrienoic acid. | 14,15-epoxy-5,8,11-eicosatrienoic acid | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Of the four regioisomers of arachidonic acid epoxides, only 14,15-epoxyeicosatrienoic acid elicited the expression of PGHS-2 in intestinal crypt epithelial cells. | 14,15-epoxy-5,8,11-eicosatrienoic acid | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | This is the first direct evidence of stimulation of an immediate-early gene product, specifically PGHS-2, by an AA epoxygenase metabolite, 14,15-epoxyeicosatrienoic acid, as well as of a heterologous regulation of PGHS-2 synthesis by these monoxygenase products. | 14,15-epoxy-5,8,11-eicosatrienoic acid | prostaglandin-endoperoxide synthase 2 | Homo sapiens |