Title : Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.

Pub. Date : 1997 Oct

PMID : 9364988






1 Functional Relationships(s)
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1 These results indicate that the size of the thrombin hydrophobic pocket S2 is sufficient to accept larger residues than proline in the P2 position of Ac-D-Phe-X-boroArg derivatives while this is not the case for other important serine-proteases of the fibrinolysis, coagulation and complement pathways. Proline coagulation factor II, thrombin Homo sapiens